endo-BCN-PEG8-Val-Cit-PAB-MMAE

PG-20161-15917

Product information

Catalog No.
PG-20161-15917
Product Name
endo-BCN-PEG8-Val-Cit-PAB-MMAE
CAS No.
Not specified
Molecular Formula
C88H143N11O23
Molecular Weight
1723.2
Purity
98%
Storage
-20°C
Shipping
Ambient Temperature
Documents

Missing values are marked “Not specified”. Request the technical information you need with your inquiry. For research use only.

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General Information

Product Name
endo-BCN-PEG8-Val-Cit-PAB-MMAE
CAS No.
Not specified
Synonyms
Not specified
Molecular Formula
C88H143N11O23
Molecular Weight
1723.2
Appearance
Not specified
Solubility
Not specified
Description

endo-BCN-PEG8-Val-Cit-PAB-MMAE is a cleavable ADC linker–payload construct containing a BCN handle, a hydrophilic PEG spacer, a Val-Cit dipeptide, a PAB motif and an MMAE payload. The BCN group reacts with azide groups on target molecules to form stable triazole linkages. Protease cleavage of the Val-Cit motif initiates an elimination mechanism within the PAB structure, releasing MMAE into cells.