DBCO-PEG12-Val-Cit-PAB-MMAE

PG-20161-48631

Product information

Catalog No.
PG-20161-48631
Product Name
DBCO-PEG12-Val-Cit-PAB-MMAE
CAS No.
Not specified
Molecular Formula
C104H160N12O27
Molecular Weight
2010.5
Purity
98%
Storage
-20°C
Shipping
Ambient Temperature
Documents

Missing values are marked “Not specified”. Request the technical information you need with your inquiry. For research use only.

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General Information

Product Name
DBCO-PEG12-Val-Cit-PAB-MMAE
CAS No.
Not specified
Synonyms
Not specified
Molecular Formula
C104H160N12O27
Molecular Weight
2010.5
Appearance
Not specified
Solubility
DMSO, DMF
Description

DBCO-PEG12-Val-Cit-PAB-MMAE is a cleavable ADC linker–payload conjugate combining an azide-reactive DBCO group, a PEG12 segment, a protease-sensitive Val-Cit dipeptide and MMAE through a self-immolative PAB motif. Protease cleavage of Val-Cit initiates PAB fragmentation and MMAE release, while the PEG12 segment increases hydrophilicity.

The DBCO group provides a site for click conjugation with azide-bearing partners. The compound has a molecular formula of C104H160N12O27 and a listed purity of 98%, with solubility in DMSO and DMF.