Lipid C2

PG-20161-54729

Product information

Catalog No.
PG-20161-54729
Product Name
Lipid C2
CAS No.
3003022-09-8
Molecular Formula
C70H142N6O6
Molecular Weight
1163.9
Purity
Not specified
Storage
-20°C
Shipping
Ambient Temperature
Documents

Missing values are marked “Not specified”. Request the technical information you need with your inquiry. For research use only.

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Packaging and pricing for PG-20161-54729
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PG-20161-547291 MGUSD 155In stock

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General Information

Product Name
Lipid C2
CAS No.
3003022-09-8
Synonyms
Not specified
Molecular Formula
C70H142N6O6
Molecular Weight
1163.9
Appearance
Not specified
Solubility
Not specified
Description

Lipid C2 is an ionizable cationic lipid used in lipid nanoparticle (LNP) research for in vivo mRNA delivery. It is cataloged within the branched and multi chargeable lipid categories. In mouse studies, reporter-mRNA LNPs containing this lipid accumulated preferentially in the liver and spleen, with limited distribution to the heart, lungs, and kidneys.

In a CT26 murine EBV-infected colon cancer model, LNPs carrying mRNA encoding LMP-2 were studied alongside an anti-PD-1 antibody. The combination reduced tumor volume and was associated with reduced T cell exhaustion and increased central and effector memory T cell populations.