(S)-C12-200 (solution in ethanol)

PG-20161-33260

Product information

Catalog No.
PG-20161-33260
Product Name
(S)-C12-200 (solution in ethanol)
CAS No.
1226552-44-8
Molecular Formula
C70H145N5O5
Molecular Weight
1137
Purity
Not specified
Storage
-20°C
Shipping
Ambient Temperature
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General Information

Product Name
(S)-C12-200 (solution in ethanol)
CAS No.
1226552-44-8
Synonyms
Not specified
Molecular Formula
C70H145N5O5
Molecular Weight
1137
Appearance
Not specified
Solubility
Not specified
Description

(S)-C12-200 (solution in ethanol) is an ethanol solution of an ionizable cationic lipid with pKa = 7.12. This isomer of C12-200 is used to formulate lipid nanoparticles (LNPs) for in vivo mRNA delivery.

In Ai14 mice, intravenous administration of LNPs containing this lipid and Cre recombinase mRNA produced a higher percentage of tdTomato+ hepatocytes, endothelial cells, and Kupffer cells in the liver than LNPs containing (R)-C12-200 and Cre mRNA. The specified storage temperature is -20°C.