NHS ester-PEG8-Val-Cit-PAB-MMAF

PG-20161-57505

Product information

Catalog No.
PG-20161-57505
Product Name
NHS ester-PEG8-Val-Cit-PAB-MMAF
CAS No.
Not specified
Molecular Formula
C82H131N11O26
Molecular Weight
1687
Purity
90%
Storage
-20°C
Shipping
Ambient Temperature
Documents

Missing values are marked “Not specified”. Request the technical information you need with your inquiry. For research use only.

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General Information

Product Name
NHS ester-PEG8-Val-Cit-PAB-MMAF
CAS No.
Not specified
Synonyms
Not specified
Molecular Formula
C82H131N11O26
Molecular Weight
1687
Appearance
Not specified
Solubility
Not specified
Description

NHS ester-PEG8-Val-Cit-PAB-MMAF is a cleavable linker–payload compound for antibody-drug conjugate (ADC) research. It combines the antitubulin agent MMAF with a Val-Cit sequence cleavable by Cathepsin B. MMAF inhibits tubulin polymerisation, disrupting cell division.

The terminal NHS ester enables coupling to amine groups, while the PEG8 segment supports increased aqueous solubility of the conjugate. The compound is listed within the ADC linker catalog under MMAF payloads and cleavable Val-Cit-MMAF linkers.