Azide-PEG4-Val-Cit-PAB-SN-38
PG-20161-73983
Product information
- Catalog No.
- PG-20161-73983
- Product Name
- Azide-PEG4-Val-Cit-PAB-SN-38
- CAS No.
- Not specified
- Molecular Formula
- C52H66N10O15
- Molecular Weight
- 1071.2
- Purity
- 98%
- Storage
- -20°C
- Shipping
- Ambient Temperature
- Documents
Missing values are marked “Not specified”. Request the technical information you need with your inquiry. For research use only.
Packaging & pricing
| Catalog No. | Packaging | Price (USD) | Stock | Inquiry action |
|---|---|---|---|---|
| PG-20161-73983 | 5 MG | Inquiry | In stock | |
| PG-20161-73983 | 10 MG | Inquiry | In stock | |
| PG-20161-73983 | 25 MG | Inquiry | In stock | |
| PG-20161-73983 | 50 MG | Inquiry | In stock |
Final pricing, package availability and delivery are confirmed with your quotation.
General Information
- Product Name
- Azide-PEG4-Val-Cit-PAB-SN-38
- CAS No.
- Not specified
- Synonyms
- Not specified
- Molecular Formula
- C52H66N10O15
- Molecular Weight
- 1071.2
- Appearance
- Not specified
- Solubility
- DMF
- Description
Azide-PEG4-Val-Cit-PAB-SN-38 combines an azide-bearing PEG spacer, a cleavable Val-Cit linker and the SN-38 payload for ADC research. SN-38 is the active metabolite of irinotecan and inhibits DNA topoisomerase I, disrupting DNA synthesis and causing single-strand breaks.
The Val-Cit segment is susceptible to cleavage by lysosomal Cathepsin B, providing a mechanism for intracellular payload release. The azide group offers a handle for click conjugation with alkyne reagents. The product has a molecular formula of C52H66N10O15, a molecular weight of 1071.2 and a listed purity of 98%; DMF is the specified solvent for solubility.