Lipid 114 (10mg/ml solution in methyl acetate)

PG-20161-78989

Product information

Catalog No.
PG-20161-78989
Product Name
Lipid 114 (10mg/ml solution in methyl acetate)
CAS No.
Not specified
Molecular Formula
C95H186N4O10
Molecular Weight
1544.6
Purity
Not specified
Storage
-20°C
Shipping
Ambient Temperature
Documents

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General Information

Product Name
Lipid 114 (10mg/ml solution in methyl acetate)
CAS No.
Not specified
Synonyms
Not specified
Molecular Formula
C95H186N4O10
Molecular Weight
1544.6
Appearance
Not specified
Solubility
Not specified
Description

Lipid 114 (10mg/ml solution in methyl acetate) is an ionizable cationic lipid with pKa = ~6.8. It has been used to prepare lipid nanoparticles (LNPs) for siRNA delivery in vitro and in vivo.

In a mouse model of acute liver failure induced by LPS and D-(+)-galactosamine, LNPs containing this lipid and IL-1β-targeted siRNA reduced hepatic and renal Il1b expression, along with hepatic inflammation and damage. The molecular formula is C95H186N4O10, and the molecular weight is 1544.6.