Lipid TG4C (10mg/ml solution in ethanol)

PG-20161-84829

Product information

Catalog No.
PG-20161-84829
Product Name
Lipid TG4C (10mg/ml solution in ethanol)
CAS No.
3028336-07-1
Molecular Formula
C55H103NO10
Molecular Weight
938.4
Purity
Not specified
Storage
-20°C
Shipping
Ambient Temperature
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General Information

Product Name
Lipid TG4C (10mg/ml solution in ethanol)
CAS No.
3028336-07-1
Synonyms
Not specified
Molecular Formula
C55H103NO10
Molecular Weight
938.4
Appearance
Not specified
Solubility
Not specified
Description

Lipid TG4C (10mg/ml solution in ethanol) is an ionizable cationic glycerolipid with pKa = 6.71. It has been used to prepare lipid nanoparticles (LNPs) for in vivo mRNA delivery and is cataloged among ionizable lipids in the L-369 & Analogs group.

In a mouse model of pulmonary emphysema induced by porcine pancreatic elastase, nebulized TG4C-containing LNPs carrying mRNA encoding human hepatocyte growth factor (HGF) reduced bronchoalveolar lavage fluid levels of Il-1β, Il-6, and Tnf-α. The specified storage temperature is -20°C.