Alloc-Val-Ala-PAB-PNP

PG-20161-31085

Product information

Catalog No.
PG-20161-31085
Product Name
Alloc-Val-Ala-PAB-PNP
CAS No.
1884578-27-1
Molecular Formula
C26H30N4O9
Molecular Weight
542.6
Purity
Not specified
Storage
-20°C
Shipping
Ambient Temperature
Documents

Missing values are marked “Not specified”. Request the technical information you need with your inquiry. For research use only.

Packaging & pricing

Packaging and pricing for PG-20161-31085
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PG-20161-31085100 MGUSD 650In stock

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General Information

Product Name
Alloc-Val-Ala-PAB-PNP
CAS No.
1884578-27-1
Synonyms
Not specified
Molecular Formula
C26H30N4O9
Molecular Weight
542.6
Appearance
Not specified
Solubility
Not specified
Description

Alloc-Val-Ala-PAB-PNP is a peptide-cleavable linker used in antibody-drug conjugate (ADC) synthesis and belongs to the Val-Ala class of cleavable ADC linkers. Its Val-Ala segment is described as susceptible to specific cleavage by Cathepsin B, while PNP serves as a leaving group.

The Alloc protecting group tolerates piperidine and TFA treatment and can be removed under mild conditions through palladium-catalyzed allyl transfer. The listed molecular formula is C26H30N4O9, with a molecular weight of 542.6.