Mal-Amide-PEG4-Val-Cit-PAB-PNP

PG-20161-33875

Product information

Catalog No.
PG-20161-33875
Product Name
Mal-Amide-PEG4-Val-Cit-PAB-PNP
CAS No.
2003260-12-4
Molecular Formula
C43H58N8O16
Molecular Weight
943
Purity
98%
Storage
-20°C
Shipping
Ambient Temperature
Documents

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General Information

Product Name
Mal-Amide-PEG4-Val-Cit-PAB-PNP
CAS No.
2003260-12-4
Synonyms
Not specified
Molecular Formula
C43H58N8O16
Molecular Weight
943
Appearance
Not specified
Solubility
DMSO, DMF
Description

Mal-Amide-PEG4-Val-Cit-PAB-PNP is a cleavable ADC linker combining a maleimide group, a hydrophilic PEG spacer, a valine-citrulline (Val-Cit) dipeptide, a para-aminobenzyl (PAB) spacer, and a para-nitrophenyl (PNP) carbonate group. The maleimide supports covalent labeling of cysteine thiols in proteins, while the activated PNP carbonate enables reaction with amines. The Val-Cit-PAB segment is susceptible to cleavage by cytoplasmic peptidases. The compound is soluble in DMSO and DMF and has a listed purity of 98%.