Mal-Dap(Boc)-Val-Cit-PAB-PNP

PG-20161-74230

Product information

Catalog No.
PG-20161-74230
Product Name
Mal-Dap(Boc)-Val-Cit-PAB-PNP
CAS No.
2281797-57-5
Molecular Formula
C37H46N8O13
Molecular Weight
810.8
Purity
Not specified
Storage
-20°C
Shipping
Ambient Temperature
Documents

Missing values are marked “Not specified”. Request the technical information you need with your inquiry. For research use only.

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General Information

Product Name
Mal-Dap(Boc)-Val-Cit-PAB-PNP
CAS No.
2281797-57-5
Synonyms
Not specified
Molecular Formula
C37H46N8O13
Molecular Weight
810.8
Appearance
Not specified
Solubility
Not specified
Description

Mal-Dap(Boc)-Val-Cit-PAB-PNP is a cleavable linker for antibody–drug conjugation, incorporating a Val-Cit segment susceptible to cathepsin B cleavage. Its maleimide functionality provides a site for conjugation with thiol groups. Following Boc deprotection and thiol attachment, intramolecular opening of the maleimide ring under aqueous conditions supports a more persistent linkage than the reversible cyclic maleimide–thiol conjugate. The listed molecular formula is C37H46N8O13.