Mal-amido-PEG8-val-gly-PAB-PNP

PG-20161-95423

Product information

Catalog No.
PG-20161-95423
Product Name
Mal-amido-PEG8-val-gly-PAB-PNP
CAS No.
Not specified
Molecular Formula
C47H66N6O19
Molecular Weight
1019.1
Purity
Not specified
Storage
-20°C
Shipping
Ambient Temperature
Documents

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Packaging & pricing

Packaging and pricing for PG-20161-95423
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General Information

Product Name
Mal-amido-PEG8-val-gly-PAB-PNP
CAS No.
Not specified
Synonyms
Not specified
Molecular Formula
C47H66N6O19
Molecular Weight
1019.1
Appearance
Not specified
Solubility
Not specified
Description

Mal-amido-PEG8-val-gly-PAB-PNP is a cleavable ADC linker with a terminal maleimide, a PEG chain, a Val-Gly dipeptide, a PAB group, and a PNP group. The maleimide forms covalent bonds with free thiols on protein cysteine residues, while the Val-Gly dipeptide is cleaved by intracellular cathepsin enzymes to support payload release. The PNP group can be substituted by amine-bearing molecules.