Lipid 331 (solution in ethanol)

PG-20161-40674

Product information

Catalog No.
PG-20161-40674
Product Name
Lipid 331 (solution in ethanol)
CAS No.
Not specified
Molecular Formula
C61H107N3O6
Molecular Weight
978.5
Purity
Not specified
Storage
-20°C
Shipping
Ambient Temperature
Documents

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General Information

Product Name
Lipid 331 (solution in ethanol)
CAS No.
Not specified
Synonyms
Not specified
Molecular Formula
C61H107N3O6
Molecular Weight
978.5
Appearance
Not specified
Solubility
Not specified
Description

Lipid 331 (solution in ethanol) is a biodegradable cyclic ionizable cationic lipid with pKa = 7.53, used in lipid nanoparticle (LNP) formulations for in vitro and in vivo mRNA delivery research. LNPs containing this lipid and 5-methoxyuridine-modified ovalbumin mRNA activated interferon regulatory factor (IRF) in a THP-1 monocyte reporter assay.

In mice, intranasal LNP formulations combining lipid 331, DOTAP, and mRNA encoding a SARS-CoV-2 spike receptor-binding domain (RBD)–mouse complement C3d fusion significantly increased serum anti-RBD IgG titers. These findings concern specific experimental formulations rather than the lipid alone.