MS-436
PG-20161-48557
Product information
- Catalog No.
- PG-20161-48557
- Product Name
- MS-436
- CAS No.
- 1395084-25-9
- Molecular Formula
- C18H17N5O3S
- Molecular Weight
- 383.4
- Purity
- 98%
- Storage
- -20°C
- Shipping
- Ambient Temperature
- Documents
Missing values are marked “Not specified”. Request the technical information you need with your inquiry. For research use only.
Packaging & pricing
| Catalog No. | Packaging | Price (USD) | Stock | Inquiry action |
|---|---|---|---|---|
| PG-20161-48557 | 50 MG | USD 180 | In stock | |
| PG-20161-48557 | 100 MG | USD 338 | In stock | |
| PG-20161-48557 | 250 MG | USD 676 | In stock |
Prices are shown in USD. Final pricing, package availability and delivery are confirmed with your quotation.
General Information
- Product Name
- MS-436
- CAS No.
- 1395084-25-9
- Synonyms
- Not specified
- Molecular Formula
- C18H17N5O3S
- Molecular Weight
- 383.4
- Appearance
- Not specified
- Solubility
- Not specified
- Description
MS-436 is a bromodomain inhibitor with an estimated Ki of 30-50 nM and a preference for the first BRD4 bromodomain over the second. Its binding involves water-mediated interactions, supporting research into the roles of BRD4 bromodomains in gene expression.
In lipopolysaccharide-stimulated mouse macrophages, it inhibits BRD4 transcriptional activity associated with nitric oxide and IL-6 production, with IC50 values of 3.8 and 4.9 μM, respectively. It is listed among BET inhibitors and has a supplied purity of 98%.