Mal-amido-PEG2-Val-Cit-PAB-OH

PG-20161-95887

Product information

Catalog No.
PG-20161-95887
Product Name
Mal-amido-PEG2-Val-Cit-PAB-OH
CAS No.
Not specified
Molecular Formula
C32H47N7O10
Molecular Weight
689.8
Purity
98%
Storage
-20°C
Shipping
Ambient Temperature
Documents

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General Information

Product Name
Mal-amido-PEG2-Val-Cit-PAB-OH
CAS No.
Not specified
Synonyms
Not specified
Molecular Formula
C32H47N7O10
Molecular Weight
689.8
Appearance
Not specified
Solubility
Not specified
Description

Mal-amido-PEG2-Val-Cit-PAB-OH is a cleavable ADC linker containing a maleimide group, a hydrophilic PEG2 spacer, a Val-Cit dipeptide segment, and a PAB moiety with a terminal benzylic alcohol. The maleimide forms covalent bonds with free thiols on protein cysteine residues, while the PAB alcohol can be activated for payload conjugation. The Val-Cit dipeptide is cleaved by intracellular proteases, triggering PAB elimination and payload release.